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Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, most commonly the small intestine and colon. It causes symptoms like abdominal pain, diarrhea, fatigue, and weight loss due to persistent inflammation triggered by an abnormal immune response.

The JAK-STAT pathway is involved in Crohn’s by transmitting signals from cytokines that promote inflammation. When overactive, it leads to excessive immune cell activation and intestinal damage. If left untreated, Crohn’s can result in complications like strictures, fistulas, malnutrition, and increased risk of surgery, significantly impacting a person’s quality of life and long-term health.

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In Crohn’s Diseases, Upadacitinib ensures
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  • Faster symptom relief Including less abdominal pain and comparatively fewer bowel movements in as early as 2 weeks.
  • Early remission without steroids at Week 12, and lasting steroid-free remission at 1 year
  • In another study, many people were in remission, even at ~2 years
  • Visibly reduced damage of the intestinal lining
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