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Atopic dermatitis (AD), or eczema, is a chronic, relapsing inflammatory skin disorder marked by dry, itchy skin (pruritus), red scaly patches (erythematous plaques), skin barrier dysfunction, and Th2-mediated immune dysregulation. The JAK-STAT pathway drives atopic dermatitis (AD) by amplifying inflammation and itch through cytokine signaling.

Cytokines (IL-4, IL-13) activate JAK1/JAK3, to promote inflammation, while IL-31 (via JAK1/JAK2) fuels chronic itch, and IL-22 disrupts the skin barrier. JAK activation also reduces filaggrin, worsening skin dryness, and sustains chronic inflammation, leading to redness and thickened skin.

[/vc_column_text][vc_empty_space height=”70px”][/vc_column][/vc_row][vc_row type=”vc_default” bg_type=”image” parallax_style=”vcpb-default” bg_image_new=”id^368|url^https://upajak.com/wp-content/uploads/2025/05/bg22-scaled.jpg|caption^null|alt^null|title^bg22|description^null” bg_image_repeat=”no-repeat” bg_img_attach=”fixed” bg_override=”ex-full”][vc_column][vc_empty_space height=”200px”][/vc_column][vc_column width=”1/3″][vc_column_text css_animation=”slideInRight” css=”” el_class=”section-img-title”]Upadacititinib inhibits JAK & helps Eczema 2 ways —[/vc_column_text][/vc_column][vc_column width=”2/3″][/vc_column][vc_column][vc_empty_space height=”200px”][/vc_column][/vc_row][vc_row type=”vc_default” css_animation=”slideInUp”][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″][vc_column_text css=””]

Fast Itch Relief Rapid & Significant Skin Clearance
  • Some people started feeling relief from itching just two days after starting treatment
  • By four months, most patients were experiencing much less itching overall
  • Some noticed 3/4 of their rash disappearing in just 2 weeks, with more seeing this improvement by 4 months
  • A number of people had all their visible eczema clear up completely by 4 months
  • Most ended up with skin that looked completely or nearly normal after treatment

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Visible improvements in skin within weeks of starting the treatment

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