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Non-radiographic means no visible structural changes on X-rays and Axial refers to mainly affecting the spine and sacroiliac joints. Non-radiographic axial spondyloarthritis (nr-axSpA) is a type of inflammatory arthritis that affects the spine and sacroiliac joints but does not show clear damage on X-rays, unlike ankylosing spondylitis.

The disease involves immune system dysregulation, where overactive signaling through the Janus kinase (JAK) pathway leads to increased production of inflammatory cytokines like IL-17 and IL-23. This causes chronic inflammation, resulting in lower back pain, morning stiffness, fatigue, and sometimes enthesitis (inflammation where tendons attach to bone) or eye inflammation.

Although not visible on X-ray, MRI can detect inflammation early. The symptoms can significantly affect daily life, making it hard to sit, walk, or sleep comfortably, and can impact work, physical activity, and emotional well-being. For adults with active non-radiographic axial spondyloarthritis who show clear signs of inflammation and have not responded adequately to a TNF blocker (Humira, Enbrel or Remicade).

[/vc_column_text][vc_empty_space height=”70px”][/vc_column][/vc_row][vc_row type=”vc_default” bg_type=”image” parallax_style=”vcpb-default” bg_image_new=”id^368|url^https://upajak.com/wp-content/uploads/2025/05/bg22-scaled.jpg|caption^null|alt^null|title^bg22|description^null” bg_image_repeat=”no-repeat” bg_img_attach=”fixed” bg_override=”ex-full”][vc_column][vc_empty_space height=”200px”][/vc_column][vc_column width=”1/3″][vc_column_text css_animation=”slideInRight” css=”” el_class=”section-img-title”]Upadacitinib —[/vc_column_text][/vc_column][vc_column width=”2/3″][/vc_column][vc_column][vc_empty_space height=”200px”][/vc_column][/vc_row][vc_row type=”vc_default” css_animation=”slideInUp”][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″ el_class=”relief-table-container”][bsf-info-box icon_type=”custom” icon_img=”id^511|url^https://upajak.com/wp-content/uploads/2025/06/pain.png|caption^null|alt^null|title^pain|description^null” img_width=”60″ pos=”left” desc_font_size=”desktop:22px;” desc_font_color=”#074580″]Ease back pain and stiffness caused by non-radiographic axial spondyloarthritis.[/bsf-info-box][bsf-info-box icon_type=”custom” icon_img=”id^510|url^https://upajak.com/wp-content/uploads/2025/06/activity.png|caption^null|alt^null|title^activity|description^null” img_width=”60″ pos=”left” desc_font_size=”desktop:22px;” desc_font_color=”#074580″]Lower overall disease activity in non-radiographic axial spondyloarthritis, as assessed covering various symptoms such as back pain, joint pain and swelling, enthesitis (inflammation in areas like the heel or elbow), fatigue, and morning stiffness.[/bsf-info-box][bsf-info-box icon_type=”custom” icon_img=”id^512|url^https://upajak.com/wp-content/uploads/2025/06/physical.png|caption^null|alt^null|title^physical|description^null” img_width=”60″ pos=”left” desc_font_size=”desktop:22px;” desc_font_color=”#074580″]Improve physical mobility and daily functions.[/bsf-info-box][/vc_column][vc_column width=”1/6″][/vc_column][/vc_row]